The outmanned Privateers opened the scoring with a Lamont Berzat-to-Damion Rosser alleyoop, but never led again in a 99-57 battering at Pitt.
The ACC's Panthers had their way with New Orleans most of the night, as UNO endured its second-to-last money game before the beginning of conference play.
Bryson Robinson led the Privateers with 11 points, and Gerrale Gates and Rosser added 10 each.
New Orleans' final nonconference game will come after a Christmas break, on December 29 at Baylor.